Upper Year Chapters | Over 130 Lessons
Building Blocks of Life
> Biological Molecules
- Lesson 1 | Chemical Structure
- Lesson 2 | Categories
- Lesson 3 | Sugars | Part 1
- Lesson 4 | Sugars | Part 2
- Lesson 5 | Lipids | Part 1
- Lesson 6 | Lipids | Part 2
- Lesson 7 | Nucleotides
- Lesson 8 | Amino Acids
> Protein Structure
- Lesson 1 | Proteins are Everything
- Lesson 2 | Primary and Secondary Structure | Alpha Helicies
- Lesson 3 | Primary and Secondary Structure | Beta Sheets
- Lesson 4 | Tertiary and Quaternary Structure | Part 1
- Lesson 5 | Tertiary and Quaternary Structure | Part 2
> Protein Function
- Lesson 1 | Binding Affinity and Conformational Change | Part 1
- Lesson 2 | Binding Affinity and Conformational Change | Part 2
- Lesson 3 | Enzymes
DNA
> The Building Blocks of Nucleic Acids
- Lesson 1 | Nucleosides
- Lesson 2 | Ribose and Deoxyribose
- Lesson 3 | Nucleotides
> DNA Structure | The Basics
- Lesson 1 | Introduction to DNA Structure | Part 1
- Lesson 2 | Introduction to DNA Structure | Part 2
- Lesson 3 | The Base Pair
- Lesson 4 | Complementary Base Pairing | Part 1
- Lesson 5 | Complementary Base Pairing | Part 2
- Lesson 6 | Polarity
> DNA Structure with a Twist
- Lesson 1 | The Double Helix
- Lesson 2 | Major and Minor Grooves
Plasma Membrane
The Nature of the Plasma Membrane
- Lesson 1 | A Selective Hydrophobic Barrier
- Lesson 2 | Oil and Water
- Lesson 3 | The Lipid Bilayer
- Lesson 4 | Phospholipids
- Lesson 5 | Phospholipid Packing | Part 1
- Lesson 6 | Phospholipid Packing | Part 2
- Lesson 7 | Plasma Membrane Functions
A Fluid Mosaic
- Lesson 1 | The Plasma Membrane is a 2D Fluid
- Lesson 2 | Regulating Plasma Membrane Fluidity
- Lesson 3 | Lipid Rafts
- Lesson 4 | The Plasma Membrane is Asymmetrical
Plasma Membrane Proteins
- Lesson 1 | Integral or Peripheral
Transmembrane Proteins
- Lesson 1 | Three Distinctive Domains
- Lesson 2 | The Power of Hydrophillic Interactions
- Lesson 3 | The Transmembrane Domain
- Lesson 4 | Examples of Transmembrane Proteins
Gene Expression, Protein Production, and Degradation
Transcription in Prokaryotes
- Lesson 1 | Initiation and Elongation
- Lesson 2 | Termination
Transcription Regulation | Lac Operon
- Lesson 1 | It’s All About Efficiency
- Lesson 2 | Glucose and Lactose | Four Possible Combinations
- Lesson 3 | The Lac Operon
- Lesson 4 | Lactose Detection | The Repressor and the Operators
- Lesson 5 | Glucose Detection | The Catabolite Activator Protein (CAP)
- Lesson 6 | Visualizing Gene Regulation
Transcription in Eukaryotes
- Lesson 1 | Genreal Overview
- Lesson 2 | Promoters
- Lesson 3 | PIC Assembly | TFIID
- Lesson 4 | PIC Assembly | TFIIA and TFIIB
- Lesson 5 | PIC Assembly | RNA Polymerase II, TFIIF, and TFIIE
- Lesson 6 | PIC Assembly | TFIIH and Mediator
- Lesson 7 | Open Complex Formation
Translation
- Lesson 1 | Introduction
- Lesson 2 | Initiation
- Lesson 3 | Elongation | Part 1
- Lesson 4 | Elongation | Part 2
- Lesson 5 | Elongation | Part 3
- Lesson 6 | Termination
Proteasome Degradation
- Lesson 1 | Proteasome Degradation
Cell Communication and Signal Transduction
Introduction
- Lesson 1 | All Cells Communicate
- Lesson 2 | How Cells Communicate
- Lesson 3 | Modes of Communication
- Lesson 4 | Filtering out Noise (Audio Only)
Introduction to Receptors
- Lesson 1 | General Overview
- Lesson 2 | Three Categories of Receptors
- Lesson 3 | Intracellular Switches | ATP
- Lesson 4 | Intracellular Switches | GTP
G-Protein-Coupled Receptors (GPCRs)
- Lesson 1 | GPCR and Structure/Function Relationship
- Lesson 2 | G-Protein Structure/Function Relationship
- Lesson 3 | Heterotrimeric G-Protein Targets
- Lesson 4 | Adenylate Cyclase (AC) and PKA
- Lesson 5 | PLC, IP3, and DAG | Part 1
- Lesson 6 | PLC, IP3, and DAG | Part 2
- Lesson 7 | Example | Blood Glucose Regulation | Part 1
- Lesson 8 | Example | Blood Glucose Regulation | Part 2
Enzyme-Coupled Receptors
- Lesson 1 | General Overview
- Lesson 2 | RTK Str/Fun Relationship/Dimerization | Part 1
- Lesson 3 | RTK Str/Fun Relationship/Dimerization | Part 2
- Lesson 4 | Activation via Trans-Autophosphorylation
- Lesson 5 | Recruit. Intracell. Sig. Proteins | Part 1
- Lesson 6 | Recruit. Intracell. Sig. Proteins | Part 2
- Lesson 7 | Ras | Monomeric G-Protein
RTK Examples
- Lesson 1 | MAPK | Part 1
- Lesson 2 | MAPK | Part 2
- Lesson 3 | Insulin Receptor | Part 1
- Lesson 4 | Insulin Receptor | Part 2
- Lesson 5 | Insulin Receptor | Part 3
Calcium Signaling
- Lesson 1 | Calcium and Calmodulin
- Lesson 2 | CaMKII | Structure and Function
- Lesson 3 | CaMKII | Initial Activation
- Lesson 4 | CaMKII | Persistent Activation
Crosstalk
- Lesson 1 | Crosstalk Signaling
Mitochondria and Aerobic Respiration (Introduction)
Introduction
- Lesson 1 | The Mitochondrion | A Relic of History | Part 1
- Lesson 2 | The Mitochondrion | A Relic of History | Part 2
Mitochondria Structure and Composition
- Lesson 1 | Morphology and Compartments
- Lesson 2 | Outer Membrane
- Lesson 3 | Inner Membrane
- Lesson 4 | Central Dogma | Part 1
- Lesson 5 | Central Dogma | Part 2
The Mitochondrial Power Plant
- Lesson 1 | Aerobic Respiration | The Big Picture | Part 1
- Lesson 2 | Aerobic Respiration | The Big Picture | Part 2
Extracting Electrons
- Lesson 1 | Glycolysis | The Preparation Phase | Steps 1-5
- Lesson 2 | Glycolysis | The Electron Extraction Phase | Steps 6-10
Protein Trafficking
Introduction to Protein Trafficking
- Lesson 1 | The Protein Trafficking Machinery
- Lesson 2 | One Starting Point, Two Possible Paths | 1. Cytosolic
- Lesson 3 | One Starting Point, Two Possible Paths | 2. Endomembrane
Cytosolic Trafficking
- Lesson 1 | Nuclear Targeting | The Nuclear Envelope
- Lesson 2 | Nuclear Targeting | The Nuclear Pore Complex (NPC) | Part 1
- Lesson 3 | Nuclear Targeting | The Nuclear Pore Complex (NPC) | Part 2
- Lesson 4 | Nuclear Targeting | The Ran-GTP Cycle | Part 1
- Lesson 5 | Nuclear Targeting | The Ran-GTP Cycle | Part 2
- Lesson 6 | Trafficking to Mitochondria
Endomembrane Trafficking | The Endoplasmic Reticulum (ER)
- Lesson 1 | Introduction to the Endoplasmic Reticulum (ER)
- Lesson 2 | Translation into the ER | Soluble Proteins | Part 1
- Lesson 3 | Translation into the ER | Soluble Proteins | Part 2
- Lesson 4 | Translation into the ER | Transmembrane Proteins
DNA Replication
DNA Replication in Prokaryotes
- Lesson 1 | Initiation | Part 1
- Lesson 2 | Initiation | Part 2
- Lesson 3 | Replisome Assembly | Part 1
- Lesson 4 | Replisome Assembly | Part 2
- Lesson 5 | Elongation | Helicase and Gyrase
- Lesson 6 | Elongation | DNA Polymerase III
- Lesson 7 | Elongation | DNA Polymerase I and Ligase
Metals in Biology
Copper Uptake
- Lesson 1 | Copper Uptake | Inroduction
- Lesson 2 | hCTR1 Transporter | Structure | Part 1
- Lesson 3 | hCTR1 Transporter | Structure | Part 2
- Lesson 4 | hCTR1 Transporter | Function
